Get up, Stand up, and you might experience cognitive deficits as well.
“Stand Corrected” talks about a study in which it was found that folks who suffer Orthostatic Hypotension when standing up also show some loss of cogniitive function, which is corrected when lying down,
Systematic review of studies involving Nordic Walking and Parkinson’s was conducted. Due to differences in study designs, can’t really say whether NW should be included in exercise treatments for folks with PD.
It is well known that physical exercise is the main therapeutic element of rehabilitation programs for people with Parkinson’s disease (PD). As traditional forms of exercise can guarantee significant health benefits, the emergence of non-conventional physical activities, such as Nordic walking (NW), may add positive effects.
To appraise the available evidence on the main effects of NW in the rehabilitation programs for people with PD and to propose a design for upcoming research that might improve the uniformity of future trials.
A literature search of five established databases (PubMed, MEDLINE, Scopus, Web of Science and Cochrane) was conducted.
ology. Any relevant randomized controlled trials (RCTs) pertinent to NW in PD published in English from inception to February 2017, were included. PRISMA guidelines were followed and the methodological quality of each study was assessed by the PEDro scale.
Sixty-six studies were retrieved and 6 RCTs (221 subjects) entered the qualitative synthesis. Overall, these studies portrayed NW as feasible and likely to be effective in improving the functional and clinical outcomes of people with PD. When comparing NW with other exercise-based interventions such as treadmill training, free walking, a program of standardized whole-body movements with maximal amplitude (LSVT®BIG training) or a home-based exercise program, the findings proved controversial.
High heterogeneity and methodological discrepancies among the studies prevent from drawing firm conclusions on the effectiveness of NW in comparison with other exercise-based interventions currently employed in people with PD. Further investigations with a common design are necessary to verify whether NW may be included within conventional rehabilitation programs commonly recommended to people with PD.
Original of this story at: Medical News Today web site 21 June 2017
The exact causes of Parkinson’s disease are unknown, but an important hallmark is the buildup of damaged alpha-synuclein protein in dopamine-producing cells.
The new study reveals evidence that two fragments of alpha-synuclein can trigger T cells to initiate an attack by the immune system.
The researchers tested blood samples from 67 patients with Parkinson’s disease and control samples from 36 healthy patients.
They exposed the blood samples to fragments of proteins found in brain cells, including fragments of alpha-synuclein. The blood from the controls hardly reacted, but T cells in the blood from the Parkinson’s patients had a strong reaction to defined fragments from alpha-synuclein
The finding suggests that certain variants of MHC – such as those associated with Parkinson’s disease – may cause T cells to mistakenly identify the alpha-synuclein fragments as pathogens and thus trigger an autoimmune response that destroys the offending cells.
A lot of work still needs to be done,, but it could help to provide a diagnostic test for risk or early stages of PD, which is sorely needed.
I wonder – Could you get allergy shots with alpha synuclein protein fragments to reduce or eliminate the autoimmune response and thus keep T-Cells from attacking the dopaminergic neurons?
I had my DNA analyzed by 23AndMe and in addition to getting some somewhat innocuous reports on my genetic makeup (including the revelation that there is about .5% match each with Askenazi and African groups somewhere in my ancestry, plus some Neanderthal genes) my data has been anonymously included in nine published articles/studies so far, including:
- 23and Me blog article on Depression and genes: https://blog.23andme.com/23andme-research/new-genetic-findings-on-depression/ The original (abstract of) the article on genes associated with depression: http://www.nature.com/ng/journal/v48/n9/full/ng.3623.html
- On genes related to risks of basal cell carcinoma: https://blog.23andme.com/23andme-research/new-study-on-genetics-of-common-type-of-skin-cancer/ Original article in Nature Communications: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992160/
- AND OTHERS which can be found at 23AndMe Blog – Research category
Live long and Prosper!
Medscape reports on new research results from the International Conference on Parkinson’s Disease and Movement Disorders, held in Vancouver, BC, Canada June 4 – 8 2017.
When viewing pictures of cats and dogs with no distortion, medium distortion, and strong distortion, Parkinson’s Patients did worse than controls in distinguishing between cats and dogs in the medium distortion condition, pointing to possible improved tests and treatments to prevent dementia in Parkinson’s.
Autopsy studies of patients with PD confirm that this area of the brain — the infero-temporal and parieto-occipital cortex — is affected, she noted. “So we already know that there is some clue that the visual processing part of the brain is important.”
Current visuo-perceptual tests measure only one or two aspects of visual processing and tend to be “too easy,” said Dr Weil. “Everyone does very well on them and by the time they do badly, their disease may have progressed quite a bit. We need trickier tests.”
As well, current tests measure visual processing only in small numbers of patients. Online testing enables access to large numbers of patients.
“People think of PD as a disorder of movement but it’s much more complex and affects much more than just movement.”
A key question then, she said, is how does PD affect the brain? “Whatever it is that causes PD doesn’t just involve the deep part of the brain, but also involves the thinking and memory parts, and the fact that people have trouble with these tests suggests that those bits are involved.”
This is just a reference to an article and its abstract, nothing more, nothing less.
Multidimensional measurement of exposure to music in childhood: Beyond the musician/non-musician dichotomy
Much research in music psychology characterizes the music background of its participants in a dichotomous manner, labeling participants as “musicians” and “non-musicians” or professionals and non-professionals. However, this terminology is inconsistent from study to study, and even more sophisticated measures fail to accurately represent music experiences; moreover, there is no standardized measure suitable for use with younger participants. This article presents a new measure, the Exposure to Music in Childhood Inventory, for capturing the amount and type of exposure to music activities suitable for use with children. Children from public and private school, aged 5 to 13 years old (N = 1006; M = 8.36 years old, SD = 1.5 years) completed the inventory, and through a combination of exploratory and confirmatory factor analysis a two-factor solution was obtained. The first factor includes personal music listening activities, home musical environment and the influence of television and the internet; the second reflects more social, active and public elements of music-making, playing an instrument and performing. This scale is suitable for use in a wide range of future research to more accurately assess the kinds of music activities children have access to in a dimensional way, which can have a bearing on their understanding of music.
Link to full article: http://jamanetwork.com/journals/jama/fullarticle/2630954
(I know how to embed a link inside text – just chose not to do it that way this time, thanks for the advice, folks). Here’s a couple of quotes from the article:
Music is fundamental to the human species in ways that reach beyond entertainment or pastime. In Musicophilia, Oliver Sacks noted that music can “calm us, animate us, comfort us, thrill us, or serve to organize and synchronize us at work or play, [but] it may be especially powerful and have great therapeutic potential for patients with a variety of neurological conditions.”
. . .
Processing music is one of the most cognitively demanding tasks our brains undertake, and creating and performing music is even more complex. We are just beginning to understand what neural processes underlie the effects of active music making, and a better appreciation of these processes would likely enhance understanding of brain responses to other stimuli and tasks. There is already compelling evidence that in children, music training assists development of language skills, auditory processing, and educational achievement compared with untrained peers,2– 4 and anecdotally, many top professionals across different disciplines have musical training in their background.
The article describes the beginning of this initiative and why it is important – it will be interesting to follow this topic in the future.
Here’s the reference list from the article. More good info there.
Found an interesting site out in Califrnia, an educatioanl institution naturally, with several thought provoking titles availble for reading – originally got to the site by a link to the paper on the positive effects of music therapy .
http://digitalcommons.csumb.edu/caps_thes_all/ is a cresaative commons digital archive for the California State University, Monterey Bay.:
There is an account registration, but it is not needed to download all of the files. Some of the Capstone projects and theses that I found interesting were:
PDF A Discussion Regarding Various Animals’ Abilities to Make Music and Move Rhythmically to Songs, Emilie R. Bufford
PDF And The Beat Goes on: The Story of the Drum Machine, Ismael Medina
PDF Self-Expression Through Dance in Early Elementary School, Emily Blythe
PDF The Benefits of Outdoor Education and Experiential Learning in Elementary Schools, Elizabeth F. Valentino
Here’s a sample of links to Gut Microbiota For Health’s website and some of the research articles they’ve published, mostly in the last year. One talks about the linkage between certain bacteria and motor system disorders, another about relief for constipation for Parkinson’s patients, Another is a compilation of several articles, and finally, an article that explores the gut to brain relation regarding Parkinson’s, and to top it all off, the relationship of the bacteria in your stomach to the chemicals in your brain, and how the various microbial communities communicate. Life goes on within you and without you, it would seem.