Get up, Stand up, and you might experience cognitive deficits as well.
“Stand Corrected” talks about a study in which it was found that folks who suffer Orthostatic Hypotension when standing up also show some loss of cogniitive function, which is corrected when lying down,
Systematic review of studies involving Nordic Walking and Parkinson’s was conducted. Due to differences in study designs, can’t really say whether NW should be included in exercise treatments for folks with PD.
It is well known that physical exercise is the main therapeutic element of rehabilitation programs for people with Parkinson’s disease (PD). As traditional forms of exercise can guarantee significant health benefits, the emergence of non-conventional physical activities, such as Nordic walking (NW), may add positive effects.
To appraise the available evidence on the main effects of NW in the rehabilitation programs for people with PD and to propose a design for upcoming research that might improve the uniformity of future trials.
A literature search of five established databases (PubMed, MEDLINE, Scopus, Web of Science and Cochrane) was conducted.
ology. Any relevant randomized controlled trials (RCTs) pertinent to NW in PD published in English from inception to February 2017, were included. PRISMA guidelines were followed and the methodological quality of each study was assessed by the PEDro scale.
Sixty-six studies were retrieved and 6 RCTs (221 subjects) entered the qualitative synthesis. Overall, these studies portrayed NW as feasible and likely to be effective in improving the functional and clinical outcomes of people with PD. When comparing NW with other exercise-based interventions such as treadmill training, free walking, a program of standardized whole-body movements with maximal amplitude (LSVT®BIG training) or a home-based exercise program, the findings proved controversial.
High heterogeneity and methodological discrepancies among the studies prevent from drawing firm conclusions on the effectiveness of NW in comparison with other exercise-based interventions currently employed in people with PD. Further investigations with a common design are necessary to verify whether NW may be included within conventional rehabilitation programs commonly recommended to people with PD.
Original of this story at: Medical News Today web site 21 June 2017
The exact causes of Parkinson’s disease are unknown, but an important hallmark is the buildup of damaged alpha-synuclein protein in dopamine-producing cells.
The new study reveals evidence that two fragments of alpha-synuclein can trigger T cells to initiate an attack by the immune system.
The researchers tested blood samples from 67 patients with Parkinson’s disease and control samples from 36 healthy patients.
They exposed the blood samples to fragments of proteins found in brain cells, including fragments of alpha-synuclein. The blood from the controls hardly reacted, but T cells in the blood from the Parkinson’s patients had a strong reaction to defined fragments from alpha-synuclein
The finding suggests that certain variants of MHC – such as those associated with Parkinson’s disease – may cause T cells to mistakenly identify the alpha-synuclein fragments as pathogens and thus trigger an autoimmune response that destroys the offending cells.
A lot of work still needs to be done,, but it could help to provide a diagnostic test for risk or early stages of PD, which is sorely needed.
I wonder – Could you get allergy shots with alpha synuclein protein fragments to reduce or eliminate the autoimmune response and thus keep T-Cells from attacking the dopaminergic neurons?
I had my DNA analyzed by 23AndMe and in addition to getting some somewhat innocuous reports on my genetic makeup (including the revelation that there is about .5% match each with Askenazi and African groups somewhere in my ancestry, plus some Neanderthal genes) my data has been anonymously included in nine published articles/studies so far, including:
- 23and Me blog article on Depression and genes: https://blog.23andme.com/23andme-research/new-genetic-findings-on-depression/ The original (abstract of) the article on genes associated with depression: http://www.nature.com/ng/journal/v48/n9/full/ng.3623.html
- On genes related to risks of basal cell carcinoma: https://blog.23andme.com/23andme-research/new-study-on-genetics-of-common-type-of-skin-cancer/ Original article in Nature Communications: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992160/
- AND OTHERS which can be found at 23AndMe Blog – Research category
Live long and Prosper!
Medscape reports on new research results from the International Conference on Parkinson’s Disease and Movement Disorders, held in Vancouver, BC, Canada June 4 – 8 2017.
When viewing pictures of cats and dogs with no distortion, medium distortion, and strong distortion, Parkinson’s Patients did worse than controls in distinguishing between cats and dogs in the medium distortion condition, pointing to possible improved tests and treatments to prevent dementia in Parkinson’s.
Autopsy studies of patients with PD confirm that this area of the brain — the infero-temporal and parieto-occipital cortex — is affected, she noted. “So we already know that there is some clue that the visual processing part of the brain is important.”
Current visuo-perceptual tests measure only one or two aspects of visual processing and tend to be “too easy,” said Dr Weil. “Everyone does very well on them and by the time they do badly, their disease may have progressed quite a bit. We need trickier tests.”
As well, current tests measure visual processing only in small numbers of patients. Online testing enables access to large numbers of patients.
“People think of PD as a disorder of movement but it’s much more complex and affects much more than just movement.”
A key question then, she said, is how does PD affect the brain? “Whatever it is that causes PD doesn’t just involve the deep part of the brain, but also involves the thinking and memory parts, and the fact that people have trouble with these tests suggests that those bits are involved.”
Contrary to what had been thought for many years, psychology as a science has within the last few years done research into nostalgia, and has found that it can be positive in its results.
It has been so good, in fact, that the University of Southampton in the UK has created a Nostalgia Center.
And to do research, they’ve created a Nostalgia scale for measurement.
some other overlapping research involves music and nostalgia
At UC Davis, they study how music and nostalgia interact.
It’s all good.
Dancing keeps brain’s white matter together The alternative is that as you get older, the white matter in your brain gets thinner, and there goes a lot of your higher functions.
Dancing can keep you young at Heart? At any rate, it can’t hurt. Unless you’re dancing on the edge of a razor, perhaps.
Just trying to clear up some space in my outbox.
Same thing we do every night, Pinkie – SING!!!
Okay, if you caught the reference to Pinkie and the Brain, you probably already like to do stuff that stimulates the neurons with witty references to arcane bits of history, pop culture, and the like. So you won’t be terribly disappointed if I caper about with just a few links to reports on and research on how singing benefits the brain and the lives of those who sing.
How singing makes you happy (summary article and its sources below:
- “America Ranks Choruses as #1 Form of Arts Participation.” Chorus America. Feb. 25, 2003. http://www.rrcb.org/documents/chorusamerica.doc
- Allot, Serena. “Why singing makes you happy.” Telegraph. March 26, 2009. http://www.telegraph.co.uk/health/wellbeing/5050461/Why-singing-makes-you-happy.html
- “Choral singing and psychological wellbeing: Findings from English choirs in a cross-national survey using the WHOQOL-BREF.” International Symposium on Performance Science. http://www.newcastle.edu.au/Resources/Research%20Centres/ArtsHealth/Choral-singing-and-psychological-wellbeing.pdf
- MacLean, Tamara. “Choral singing makes you happy: survey.” Sydney Morning Herald. July 10, 2008. http://news.smh.com.au/national/choral-singing-makes-you-happy-survey-20080710-3cyg.html
- “Singing to females makes male birds’ brains happy.” EurekAlert. Oct. 3, 2008. http://www.eurekalert.org/pub_releases/2008-10/plos-stf100308.php
Can Music provoke involuntary body responses? Now I’ve heard everything – using music to provoke salivation!
Here’s a sample of links to Gut Microbiota For Health’s website and some of the research articles they’ve published, mostly in the last year. One talks about the linkage between certain bacteria and motor system disorders, another about relief for constipation for Parkinson’s patients, Another is a compilation of several articles, and finally, an article that explores the gut to brain relation regarding Parkinson’s, and to top it all off, the relationship of the bacteria in your stomach to the chemicals in your brain, and how the various microbial communities communicate. Life goes on within you and without you, it would seem.